Forschungsbereiche Tulln

Biotechnology & Bioinformatics

Biosciences are currently undergoing a transformation towards high-throughput bioanalytics, enabling the holistic recording of living systems and their complex biochemical and molecular-biological interactions and structures.

In order to meet these requirements, the Biotech Campus Tulln has established a special research focus in the analytical/bioanalytical field and in the optimization of biotechnological processes. This expertise is complemented by state-of-the-art know-how in data processing and evaluation for generating insights into the growing flood of data.

Thematic stimuli are constantly being generated in cooperation with research institutes, the industrial sector and the business world. Research services are carried out both on behalf of customers directly and for research projects, funded both publicly and privately.

The main topics at the Biotech Campus Tulln range from the extraction and identification of bioactive substances to food analysis and safety and environmental biotechnology.

The most modern laboratory infrastructure and know-how are available for this purpose:

  • Chromatography (from analytical to preparative scale)
  • Mass spectrometry
  • Spectroscopic analytics (IR, Raman)
  • Molecular biological techniques (qPCR, microarrays)
  • Bioassays
  • Expression systems
  • Fermentation
  • Protein purification and analysis
  • Bioinformatics

Research Activities

  • CIM - Tumorstroma Analytik mittels Nano LC-MS/MS

    The project will use Nano LC- MS/MS to provide a deeper insight into the complex communication system of cancer cells with their neighbours and the influence of therapy on this network.

    Project Partners

    • Vet Med Uni Wien
    • Med Uni Wien
  • Myko-Ten

    This project will investigate the potential of mealworms for the degradation of mycotoxins in food and feed. At the FH, the proteome of mealworms will be isolated and qualitatively recorded using Nano LC- MS/MS.

    Project Partners

    • BOKU, Dep. IFA-Tulln
    • BIOMIN
  • OMICS 4.0

    Bioinformatics in Interdisciplinary Life Science Research- The FH module includes the bioanalytical and bioinformatic search for relationships between transcriptome and metabolome data from Fusarium-infested grain.

    Project Partners

    • BOKU, Dep. IFA-Tulln
    • AIT

Publications

Hermann, Daniel-Ralph/Lilek, David/Daffert, Christina/Fritz, Ines/Weinberger, Simone/Rumpler, Vanessa/Herbinger, Birgit/Prohaska, Katerina (2020): In situ based surface-enhanced Raman spectroscopy (SERS) for the fast and reproducible identification of PHB producers in cyanobacterial cultures. In: Analyst. Royal Society of Chemistry.
Matthias/P/Gerstl, Stefan/Müller, Georg/Regensburger, Jürgen/Zanghellini (2019): Flux tope analysis: studying the coordination of reaction directions in metabolic networks. In: https://doi.org/10.1093/bioinformatics/bty550. Oxford University Press.
Dmytro/Iurashev, Susanne/Schweiger, Alois/Jungbauer, Jürgen/Zanghellini (2019): Dissecting peak broadening in chromatography columns under non-binding conditions. In: https://doi.org/10.1016/j.chroma.2019.03.065. Elsevier B.V.
Heena/Dhiman, Matthias/P/Gerstl, David/Ruckerbauer, Michael/Hanscho, Heinz/Himmelbauer, Colin/Clarke, Niall/Barron, Jürgen/Zanghellini, Nicole/Borth (2019): Genetic and Epigenetic Variation across Genes Involved in Energy Metabolism and Mitochondria of Chinese Hamster Ovary Cell Lines. In: https://doi.org/10.1002/biot.201800681. John Wiley & Sons, Inc.
Prohaska, Katerina/Prohaska, Christian/Steffan, Ilse/ (2002): HIC separation of proteins in human blood fractions hyphenated to atomic spectrometry as detector of essential elements. In: Journal of Chromatography A (Hrsg.). Elsevier.
Ekmekcioglu, Cem/Prohaska, Christian/Prohaska, Katerina/Steffan, Ilse/Marktl, Wolfgang/Schernthaner Guntram/ (2001): Concentration of seven trace elements in different hematological matrices in patients with type 2 diabetes compared to healthy controls. In: Biological Trace Element Research (Hrsg.). Springer.
Prohaska, Katerina/Prohaska, Christian/Steffan, Ilse/ (2001): Multielement Analysis in Blood Fractions by Atomic Spectrometry after SEC or HIC Protein Separation. In: ICP Information Newsletter, Inc. (Hrsg.).
Schwarz, Gerhard/Pomazal, Katerina/Prohaska, Christian/Steffan, Ilse/Vujicic, Goran/ (2001): ICP-AES Analysis of Alloys Used for Medical Applications. In: ICP Information Newsletter, Inc. (Hrsg.).
Prohaska, Katerina/Prohaska, Christian/Steffan, Ilse/Reich, Gregor/Huber, Josef.F.K./ (2000): Determination of Cu, Fe, Mn, and Zn in Blood Fractions by SEC-HPLC / ICP-AES coupling. In: Analyst (Hrsg.). Royal Society of Chemistry.
Prohaska, Christian/Prohaska, Katerina/Steffan, Ilse/Törvényi, András (2000): Optimization of different atomic spectrometric methods for the determination of Se in blood and blood fractions. In: Journal of Analytical Atomic Spectroscopy (Hrsg.): Journal of Analytical Atomic Spectroscopy. Royal Society of Chemistry.
Prohaska, Christian/Steffan, Ilse/Prohaska, Katerina/ (2000): Determination of Ca, Mg, Fe, Cu, and Zn in blood fractions and whole blood of humans by ICP-AES. In: Fresenius Journal of Analytical Chemistry (Hrsg.). Fresenius.
Prohaska, Christian/Steffan, Ilse/Prohaska, Katerina/ (2000): ETAAS method for the determination of Cd, Cr, Cu, Mn, and Se in blood fractions and whole blood. In: Fresenius Journal of Analytical Chemistry (Hrsg.). Fresenius.

Contact

Feel free to contact us: f&e@fhwn.ac.at