FHWN 0519 4888 Pletterbauer

Biomedical Engineering

Preclinical Multimodal Imaging (PMI) - Research Labs

Molecular imaging plays a central role in modern medicine as well as biomedical research to study regional or systemic tissue properties in a non-invasively manner. It comprises the real-time visualization and quantification of biochemical events at the cellular and molecular level within living cells, biological and artificial tissues and living subjects. The application of molecular imaging techniques, comprising the development and evaluation of novel imaging biomarkers for specific biological and biochemical processes, in combination with traditional imaging modalities, has the potential to provide essential comprehensive information on tumor heterogeneity that benefits in radiation therapy.

Preclinical multimodal molecular imaging and specific biomedical image quantification procedures are useful tools to foster the understanding of the systems biology of tumors, increasing the knowledge about radiobiological aspects and help to facilitate the integration in the field of radiation therapy planning, verification and treatment monitoring.

In this context, a preclinical imaging facility comprising micro-positron-emission-tomography (µPET), micro-single-photon-emission-computed-tomography (µSPECT) and micro-computed-tomography (µCT) is implemented in the research infrastructure of the ion therapy and research center – MedAustron. Collaborative research between the University of Applied Sciences Wiener Neustadt and the Medical University of Vienna, in the field of molecular imaging sciences, medical physics and radiation biology are performed.

Infrastructure:

  • µCT
  • µPET
  • µSPECT
  • µMRI
  • Gamma Counter
  • Isoflurane vaporizer
  • Dose calibrator
  • Laminar airflow
  • Image quantification software
  • Nuclear medicine lab

MedTech - International Masters Programme for Functional Imaging, Conventional and Ion Radiotherapy

Publications

Zimmermann, Lukas/ Buschmann, Martin/ Herrmann, Harald / Heilemann, Gerd / Kuess, Peter / Goldner, Gregor / Nyholm, Tufve / Georg, Dietmar /Nesvacil, Nicole (2021): An MR-only acquisition and artificial intelligence based image-processing protocol for photon and proton therapy using a low field MR. In: https://doi.org/10.1016/j.zemedi.2020.10.004.
Zopf, L.M./Heimel, P./Geyer, S.H./Kavirayani, A./Reier, S./Fröhlich, V./Stiglbauer-Tscholakoff, A./Chen, Z./Nics, L./Zinnanti, J./Drexler, W./Mitterhauser, M./Helbich, T./Weninger, W.J./Slezak, P./Obenauf, A./Bühler, K./Walter, A. (2021): Cross-Modality Imaging of Murine Tumor Vasculature—a Feasibility Study. In: Molecular Imaging and Biology (Hrsg.). Springer.
Zimmermann, Lukas/Faustmann, Erik/Ramsl, Christian/Georg, Dietmar/Heilemann, Gerd (2021): Technical Note: Dose prediction for radiation therapy using feature-based losses and One Cycle Learning. In: doi.org/10.1002/mp.14774.
Irmak, Sinan/Zimmermann, Lukas /Georg, Dietmar/Kuess, Peter/Lechner, Wolfgang (2021): Cone beam CT based validation of neural network generated synthetic CTs for radiotherapy in the head region. In: doi.org/10.1002/mp.14987.
Fuchs, Hermann /Padilla-Cabal, Fatima/Zimmermann, Lukas/Palmans, Hugo/Georg, Dietmar (2021): MR-guided proton therapy: Impact of magnetic fields on the detector response. In: doi.org/10.1002/mp.14660.
Fetty, Lukas / Bylund, Mikael / Kuess, Peter / Heilemann, Gerd / Nyholm, Tufve / Georg, Dietmar / Löfstedt, Tommy (2020): Latent space manipulation for high-resolution medical image synthesis via the StyleGAN. In: doi.org/10.1016/j.zemedi.2020.05.001.
Fetty, Lukas / Löfstedt, Tommy / Heilemann, Gerd / Furtado, Hugo / Nesvacil, Nicole / Nyholm, Tufve / Georg, Dietmar / Kuess, Peter (2020): Investigating conditional GAN performance with different generator architectures, an ensemble model, and different MR scanners for MR-sCT conversion. In: doi.org/10.1088/1361-6560/ab857b.
Schuetzenberger, K./Pfister, M./Messner, A./Froehlich, V./Garhoefer, G./Hohenadl, C./Schmetterer, L./Werkmeister, R. M. (2019): Comparison of optical coherence tomography and high frequency ultrasound imaging in mice for the assessment of skin morphology and intradermal volumes. In: https://doi.org/10.1038/s41598-019-50104-4. Sci Rep-UK.
Padilla-Cabal, Fatima/Kuess, Peter/Georg, Dietmar/Palmans, Hugo/Fetty, Lukas/Fuchs, Hermann (2019): Characterization of EBT3 radiochromic films for dosimetry of proton beams in the presence of magnetic fields. In: doi.org/10.1002/mp.13567.
Vraka, C./Mijailovic, S./Fröhlich, V./Zeilinger, M./Klebermass, E.-M./Wadsak, W./Wagner, K.-H./Hacker, M./Mitterhauser, M. (2018): Expanding LogP: Present possibilities. In: https://doi.org/10.1016/j.nucmedbio.2017.11.007. Nucl Med Biol.
Heilemann, Gerd/Fetty, Lukas/Blaickner, Matthias/Nesvacil, Nicole/Zehetmayer, Martin/Georg, Dietmar/Dunavoelgyi, Roman (2018): Retina dose as a predictor for visual acuity loss in 106 Ru eye plaque brachytherapy of uveal melanomas. In: doi.org/10.1016/j.radonc.2017.11.010.
Heilemann, Gerd/Fetty, Lukas/Dulovits, Martin/Blaickner, Matthias/Nesvacil, Nicole/Georg, Dietmar/Dunavoelgyi, Roman (2017): Treatment plan optimization and robustness of 106 Ru eye plaque brachytherapy using a novel software tool. In: doi.org/10.1016/j.radonc.2017.01.010.
MedTech_research_ban2

Contact

Feel free to contact us: FuE@fhwn.ac.at