20180918 FHWN 2016 64037 BEA Himmelverlaengert Dunkelblau ansicht

Markus Zeilinger

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Markus Zeilinger



Head of Bachelor Radiological Technology
Head of Master MedTech - functional Imaging, Conventional and Ion Radiotherapy
Head of Lehrgang Diagnostischer Ultraschall - Sonographie
Head of Kompetenzzentrum für Präklinische Bildgebung und Medizintechnik


Campus 1 Wiener Neustadt
Johannes Gutenberg-Straße 3
2700 Wiener Neustadt
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Research Activities

  • Angewandte molekulare Bildgebung

    The current project aimed to foster the understanding of the systems biology of a various number of different tumor entities, increasing the knowledge about radiobiological aspects and help to facilitate the integration in the field of radiation therapy planning, verification and treatment monitoring. In this context, the planned R&D research infrastructure will be implemented in the research facilities of the University of Applied Sciences Wiener Neustadt and the ion therapy and research center – MedAustron to support (1) expert training of students and scientific staff in theoretical (lectures) and practical (“hands-on training) aspects of preclinical molecular imaging techniques, (2) collaborative research especially in the field of functional imaging, medical physics and radiation biology to investigate molecular changes in tumor biology and microenvironment during radiotherapy, (3) acquisition, performance analysis and verification of preclinical imaging techniques in radiation therapy. The intention of the R&D research infrastructure is to provide the basis for cutting-edge biomedical research in the field of both conventional and ion radiotherapy in a regional, national and international context. In addition the project benefits and increase the quality of the education in the academic environment (students, scientific staff, etc…) in the field of quantitative molecular imaging, medical physics, radiobiology, radiation therapy planning and verification and helps to increase the understanding of (patho)physiological processes concerning the systems biology of a various number of different tumor entities.


    Given the importance of successful implantation procedures, the study of osseointegration and the factors influencing this process is a leading topic in orthopedics and dentistry. The rat tibia implantation model is a widespread animal test that evaluates the osseointegration of implants under pre-clinical conditions in vivo, for instance, to determine whether a newly developed implant meets compatibility, safety, and mechanical stability requirements. This proposal follows the hypothesis that the application of tailored surgical guides improves the accuracy, precision, and reproducibility of implant positioning, as well as the overall performance of the rat tibia implantation model, thereby resulting in the refinement and reduction of animal testing for osseointegration studies.

  • PAIR

    Cancer therapy has experienced a rapid surge in the use of protons and carbon ions, over high-energy photons. This is due to their superior physical properties, including their major energy deposition at the end of their range and their higher ionization densities of particle beams. The biological outcomes are less damage to healthy tissue, as well as altered DNA damage and cellular signaling.


  • Fuchs, Hermann/Zimmermann, Lukas/Reisz, Niklas/Zeilinger, Markus/Ableitinger, Alexander/Georg, Dietmar/Kuess, Peter (2022): Efficient full Monte Carlo modelling and multi-energy generative model development of an advanced X-ray device. In: Zeitschrift für Medizinische Physik.
  • Philippe, C/Klebermass, EM/Balber, T/Kulterer, OC/Zeilinger, M/Egger, G/Dumanic, M/Herz, CT/Kiefer, FW/Scheuba, C/Scherer, T/Fürnsinn, C/Vraka, C/Pallitsch, K/Spreitzer, H/Wadsak, W/Viernstein, H/Hacker, M/Mitterhauser, M (2021): Discovery of melanin-concentrating hormone receptor 1 in brown adipose tissue. In: Annals of the New York Academy of Sciences.
  • Ritschl, H/Zeilinger, M/Kogelbauer, H/Krasser, A (2021): Digitale Transformation und mögliche Einflussfaktoren zur Gestaltung neuer Handlungsfelder der Radiologietechnologie in Österreich. In: Radiopraxis.
  • Hayer, S/Zeilinger, M/Weiss, V/Dumanic, M/Seibt, M/Niederreiter, B/Shvets,T/ Pichler, F/Wadsak, W/Podesser, B/Helbich, T/Hacker, M/Smolen,JS/Redlich, K/Mitterhauser, M (2019): Multimodal [18F]FDG PET/CT is a direct readout for inflammatory bone repair: a longitudinal study in TNFα transgenic mice. In: Journal of Bone and Mineral Research.
  • Philippe, C/Zeilinger, M/Dumanic, M/Pichler, F/Fetty, L/Vraka, C/Balber, T/Wadsak, W/Pallitsch, K/Spreitzer, H/Lanzenberger, R/Hacker, M/Mitterhauser, M (2018): SNAPshots of the MCHR1: A comparison between the PET-tracers [18F]FE@SNAP and [11C]SNAP-7941. In: Molecular Imaging and Biology.
  • Vraka, C/Mijailovic, S/Fröhlich, V/Zeilinger, M/Klebermass, EM/Wadsak, W/Wagner, KH/Hacker, M/Mitterhauser, M (2018): Expanding LogP: Present possibilities. In: Nuclear Medicine and Biology.
  • Zeilinger, M/Dumanic, M/Pichler, F/Budinsky, L/Wadsak, W/Pallitsch, K/Spreitzer, H/Lanzenberger, R/Hacker, M/Mitterhauser, M/Philippe, C (2017): In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system. In: Nature - Scientific Reports.
  • Zeilinger, M/Pichler, F/Nics, L/Wadsak, W/Spreitzer, H/Hacker, M/Mitterhauser, M (2017): New approaches for the reliable in vitro assessment of binding affinity based on high-resolution real-time data acquisition of radioligand-receptor binding kinetics. In: European Journal of Nuclear Medicine and Molecular Imaging Research.
  • Philippe, C/Haeusler, D/Scherer, T/Fürnsinn, C/Zeilinger, M/Wadsak, W/Shanab, K/Spreitzer, H/Hacker, M/Mitterhauser, M (2016): [(18)F]FE@SNAP-a specific PET tracer for melanin-concentrating hormone receptor 1 imaging? In: European Journal of Nuclear Medicine and Molecular Imaging Research.
  • Haeusler, D/Kuntner, C/Nics, L/Savli, M/Zeilinger, M/Wanek, T/Karagiannis, P/Lanzenberger, R/Langer, O/Shanab, K/Spreitzer, H/Wadsak, W/Hacker, M/Mitterhauser, M (2015): [18F]FE@SUPPY: a suitable PET tracer for the adenosine A3 receptor? An in vivo study in rodents. In: European Journal of Nuclear Medicine and Molecular Imaging.
  • Philippe, C/Zeilinger, M/Mitterhauser, M/Dumanic, M/Lanzenberger, R/Hacker, M/Wadsak, W (2015): Parameter evaluation and fully-automated radiosynthesis of [11C]harmine for imaging of MAO-A for clinical trials. In: Applied Radiation and Isotopes.
  • Philippe, C/Nics, L/Zeilinger, M/Kuntner, C/ Wanek, T/Mairinger, S/Shanab, K/Spreitzer, H/Viernstein, H/Wadsak, W/Mitterhauser, M (2013): Preclinical in vitro & in vivo evaluation of [11C]SNAP-7941 - The first PET tracer for the melanin concentrating hormone receptor 1. In: Nuclear Medicine and Biology.
  • Philippe, C/Nics, L/Zeilinger, M/Schirmer, E/Spreitzer, H/Karanikas, G/Lanzenberger, R/Viernstein, H/Wadsak, W/Mitterhauser, M (2013): Preparation and first preclinical evaluation of [18F]FE@SNAP: a potential PET tracer for the melanin concentrating hormone receptor 1 (MCHR1). In: Scientia Pharmaceutica.
  • Philippe, C/Ungersboeck, J/Schirmer, E/Zdravkovic, M/Nics, L/Zeilinger, M/Shanab, K/Lanzenberger, R/Karanikas, G/Spreitzer, H/Viernstein, H/Mitterhauser, M/Wadsak, W (2012): FE@SNAP - A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): Microfluidic and vessel-based approaches. In: Bioorganic and Medicinal Chemistry.
  • Nics, L/Hahn, A/Zeilinger, M/Vraka, C/Ungersboeck, J/Haeusler, D/Hartmann, S/Wagner, KH/Lanzenberger, R/Wadsak, W/Mitterhauser, M (2012): Quantification of the radio-metabolites of the serotonin-1A receptor radioligand [carbonyl-11C]WAY-100635 in human plasma: An HPLC-assay which enables measurement of two patients in parallel. In: Applied Radiation and Isotopes.
  • Haeusler, D/Kuntner, C/Mien, LK/Wanek, T/Nics, L/Zeilinger, M/Langer, O/Dudczak, R/Wadsak, W/Mitterhauser, M (2011): In-vivo evaluation of an Adenosine A(3) receptor PET-tracer: a micro-PET study with [(18)F]FE@SUPPY. In: Journal of Labelled Compounds and Radiopharmaceuticals.
  • Zeilinger, M (2011): Entwicklung neuer Radiopharmaka für die molekulare Bildgebung: Evaluierung der Bindungsparameter von Radioliganden durch die Echtzeitquantifizierung der Bindungskinetik mithilfe der LigandTracer®-Technologie. In: Radiopraxis.