The research project CO-INNO-LAB investigates regional success factors and models for co-innovation in university-run innovation labs. Studies are conducted with regional com-panies in the region, in particular small and medium-sized industrial companies (KMI), using methods of classic social research and innovative methods of intervention and action research. The role of infrastructures (university innovation labs) should also be examined. For this pur-pose, a innovation lab will be built. Another goal is to research the possibilities of digitizing the co-innovation process via combined real-virtual (cyber-physical) innovation spaces. The knowledge gained should be made available as recommendations for action, best practices and, in the case of technical developments, as conceptual prototypes.