The current project aimed to foster the understanding of the systems biology of a various number of different tumor entities, increasing the knowledge about radiobiological aspects and help to facilitate the integration in the field of radiation therapy planning, verification and treatment monitoring. In this context, the planned R&D research infrastructure will be implemented in the research facilities of the University of Applied Sciences Wiener Neustadt and the ion therapy and research center – MedAustron to support (1) expert training of students and scientific staff in theoretical (lectures) and practical (“hands-on training) aspects of preclinical molecular imaging techniques, (2) collaborative research especially in the field of functional imaging, medical physics and radiation biology to investigate molecular changes in tumor biology and microenvironment during radiotherapy, (3) acquisition, performance analysis and verification of preclinical imaging techniques in radiation therapy. The intention of the R&D research infrastructure is to provide the basis for cutting-edge biomedical research in the field of both conventional and ion radiotherapy in a regional, national and international context. In addition the project benefits and increase the quality of the education in the academic environment (students, scientific staff, etc…) in the field of quantitative molecular imaging, medical physics, radiobiology, radiation therapy planning and verification and helps to increase the understanding of (patho)physiological processes concerning the systems biology of a various number of different tumor entities.
Given the importance of successful implantation procedures, the study of osseointegration and the factors influencing this process is a leading topic in orthopedics and dentistry. The rat tibia implantation model is a widespread animal test that evaluates the osseointegration of implants under pre-clinical conditions in vivo, for instance, to determine whether a newly developed implant meets compatibility, safety, and mechanical stability requirements. This proposal follows the hypothesis that the application of tailored surgical guides improves the accuracy, precision, and reproducibility of implant positioning, as well as the overall performance of the rat tibia implantation model, thereby resulting in the refinement and reduction of animal testing for osseointegration studies.
Cancer therapy has experienced a rapid surge in the use of protons and carbon ions, over high-energy photons. This is due to their superior physical properties, including their major energy deposition at the end of their range and their higher ionization densities of particle beams. The biological outcomes are less damage to healthy tissue, as well as altered DNA damage and cellular signaling.